Diastereo- and enantioselective phase-transfer alkylation of 3-substituted oxindoles with racemic secondary alkyl halides.
نویسندگان
چکیده
A catalytic asymmetric alkylation of fully substituted enolates with racemic, non-activated secondary alkyl halides is described. The chiral 1,2,3-triazolium ion enables excellent diastereo- and enantiocontrol via enantiofacial discrimination of prochiral enolates and kinetic resolution of secondary halides.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 53 98 شماره
صفحات -
تاریخ انتشار 2017