Diastereo- and enantioselective phase-transfer alkylation of 3-substituted oxindoles with racemic secondary alkyl halides.

نویسندگان

  • Kohsuke Ohmatsu
  • Yukino Furukawa
  • Mari Kiyokawa
  • Takashi Ooi
چکیده

A catalytic asymmetric alkylation of fully substituted enolates with racemic, non-activated secondary alkyl halides is described. The chiral 1,2,3-triazolium ion enables excellent diastereo- and enantiocontrol via enantiofacial discrimination of prochiral enolates and kinetic resolution of secondary halides.

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عنوان ژورنال:
  • Chemical communications

دوره 53 98  شماره 

صفحات  -

تاریخ انتشار 2017